Altered transition metal homeostasis in Niemann–Pick disease, type C1
نویسندگان
چکیده
منابع مشابه
Essential transition metal homeostasis in plants.
The homeostasis of the essential transition metals copper, iron, manganese and zinc requires balanced activities of transporters that mediate import into the cell, distribution to organelles and export from the cell. Transcriptional control is important for the regulation of cellular homeostasis. In the case of Fe and Cu much progress has been made in uncovering the regulatory networks that med...
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Background: The protein of Niemann-pick type C1 (NPC1) gene promotes the egress of cholesterol from late endosomes and lysosomes to other cellular compartments and contributes to a process known as reverse cholesterol transport. This study aimed to examine whether promoter methylation of NPC1 is associated with risk of cardiovascular disease (CVD). Methods: Fifty CVD patients and 50 healthy sub...
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The Niemann-Pick type C1 (NPC1) protein is a key participant in intracellular trafficking of low density lipoprotein cholesterol, but its role in regulation of sterol homeostasis is not well understood. To characterize further the function of NPC1, we generated stable Chinese hamster ovary (CHO) cell lines overexpressing the human NPC1 protein (CHO/NPC1). NPC1 overexpression increases the rate ...
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For human health, transition metal accumulation in edible seeds like cereal grains is of worldwide importance, since Fe and Zn deficiencies are among the most prevalent human nutritional disorders in the world. There have been many recent developments in our understanding of the patterns in which transition metals accumulate in the seeds, the identity of some specific transporters that are requ...
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Glutathione (GSH) and its derivative phytochelatin are important binding factors in transition-metal homeostasis in many eukaryotes. Here, we demonstrate that GSH is also involved in chromate, Zn(II), Cd(II), and Cu(II) homeostasis and resistance in Escherichia coli. While the loss of the ability to synthesize GSH influenced metal tolerance in wild-type cells only slightly, GSH was important fo...
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ژورنال
عنوان ژورنال: Metallomics
سال: 2014
ISSN: 1756-5901,1756-591X
DOI: 10.1039/c3mt00308f